Semax: Dosage, Calculator & Reconstitution Guide
A nootropic heptapeptide studied for its influence on neurotrophic signaling — reconstitution math, dosing ranges, and calculator, for research context only.
What Is Semax?
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from a fragment of adrenocorticotropic hormone (ACTH 4–10) with the terminal glycine-proline motif added to improve enzymatic stability. It was developed at the Institute of Molecular Genetics in Moscow and has been used and studied in Russia for several decades, primarily as an intranasal nootropic and in acute ischemic stroke research.
The proposed mechanism most frequently cited in the literature is upregulation of BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression, along with modulation of the dopaminergic and serotonergic systems and inhibition of enkephalin-degrading enzymes. These findings come from preclinical models and Russian clinical studies; Semax is not approved by the FDA and this page is a summary of the research literature, not a health claim. For a related Russian-origin nootropic peptide with a similar intranasal profile, see Selank.
Dosing Reference
| Typical Vial Size | BAC Water Volume | Common Dose Range | Typical Frequency |
|---|---|---|---|
| 30 mg | 3.0 mL | 250–600 mcg | 1–3× daily |
| 10 mg | 1.0 mL | 250–600 mcg | 1–3× daily |
| 5 mg | 1.0 mL | 250–600 mcg | 1–3× daily |
Semax is typically dosed in micrograms (mcg). Intranasal spray formulations sold in Russia commonly deliver ~250–500 mcg per full dose (both nostrils combined).
Reconstitution & Calculator
For a 30 mg lyophilized vial, slowly add 3 mL of bacteriostatic water down the side of the vial, swirl gently until the powder fully dissolves, and store refrigerated. That yields a 10 mg/mL working concentration — a 250 mcg dose is 25 microliters (2.5 units on a U-100 insulin syringe), and a 500 mcg dose is 50 microliters (5 units). For intranasal use, the reconstituted solution can be transferred into a dropper or spray bottle at the same concentration.
Calculate your exact draw
Storage & Stability
| State | Storage | Shelf Life |
|---|---|---|
| Lyophilized (unmixed) | Refrigerate or freeze; protect from light | 12–24 months |
| Reconstituted vial | Refrigerate 2–8°C; do not freeze | ~30 days |
| Intranasal spray (pre-mixed) | Refrigerate; keep upright | Per manufacturer label |
Semax is light-sensitive. Store in the original vial or an amber container and avoid extended exposure to room temperature.
Frequently Asked Questions
Next Steps
- → Peptide Calculator for exact syringe or dropper draw math
- → Full Peptide Dosage Chart to compare across compounds
Recommended Supplier
PSPeptides carries third-party tested, research-grade Semax with published COAs.
Discount Code: BANANAS10
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