RESEARCH PROTOCOL

Selank: Dosage, Calculator & Reconstitution Guide

A GABAergic, anxiolytic nootropic peptide available via intranasal spray or subcutaneous injection — research context only.

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What Is Selank?

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the immunomodulatory peptide tuftsin, with a stabilizing tripeptide tail added to extend enzymatic half-life. It was developed at the Institute of Molecular Genetics in Moscow and has been studied primarily for anxiolytic and cognitive effects, largely through GABAergic modulation. Secondary activity in the literature includes immunomodulation via changes in cytokine balance and interferon-related gene expression.

Selank has more clinical history than most research peptides — it received Russian regulatory approval on the basis of controlled trials for generalized anxiety indications — but it lacks large-scale Western clinical data. It is not FDA-approved. This page is a summary of the published research, not a health claim. See also our overview of Semax, another Russian-origin nootropic peptide with a similar administration profile.

Intranasal vs. Subcutaneous

PRIMARY ROUTE

Intranasal Spray

Most studied route in the Russian literature
Faster CNS access via nasal mucosa
Typical concentrations of 0.15% (1.5 mg/mL) up to ~1.25 mg/mL
Dosed in mcg per spray, typically 250–300 mcg per spray
No syringe reconstitution math required for pre-made sprays

ALTERNATIVE ROUTE

Subcutaneous Injection

Standard lyophilized-vial + BAC-water reconstitution applies
Common configuration: 5 mg vial in 2 mL BAC water = 2.5 mg/mL
Dosed in mcg per injection, typically 250–500 mcg
Use the peptide calculator for exact syringe draws
Requires standard sharps, alcohol pads, refrigerated storage

Dosing Reference

Intranasal

Spray Concentration	Mcg per Spray	Sprays per Day	Typical Total Daily Dose
0.15% (1.5 mg/mL)	~250–300 mcg	2–3 sprays, 1–3× daily	500–1800 mcg
1.25 mg/mL (compounded)	~250 mcg	2–4 sprays, 1–2× daily	500–2000 mcg

Subcutaneous

Typical Vial Size	BAC Water Volume	Concentration	Common Dose Range
5 mg	2.0 mL	2.5 mg/mL	250–500 mcg, 1–2× daily
10 mg	2.0 mL	5.0 mg/mL	250–500 mcg, 1–2× daily

Selank is dosed in micrograms (mcg). Confirm units before drawing — a mg/mcg misread is a 1000× error.

Reconstitution & Calculator

For the injectable route, add bacteriostatic water slowly down the side of a 5 mg lyophilized Selank vial (typically 2 mL) and swirl gently until fully dissolved. At 2.5 mg/mL, a 250 mcg dose is 0.1 mL (10 units on a U-100 insulin syringe) and a 500 mcg dose is 0.2 mL (20 units). The nasal spray route does not require this math — pre-made sprays are dosed by number of sprays.

Calculate your exact draw

The calculator applies to the subcutaneous (injectable) form of Selank.

Calculate Your Selank Dose →View Full Dosage Chart

Storage & Stability

State	Storage	Shelf Life
Lyophilized (unmixed)	Refrigerate or freeze; protect from light	12–24 months
Reconstituted vial	Refrigerate 2–8°C; do not freeze	~30 days
Intranasal spray	Refrigerate; keep upright and away from light	~30 days once opened

Both nasal spray and reconstituted injectable forms require refrigeration and light protection.

Frequently Asked Questions

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, studied primarily for anxiolytic and cognitive effects via GABAergic modulation, with secondary effects on cytokine and interferon gene expression. It has been investigated in Russian clinical settings for generalized anxiety and stress-related conditions, but is not FDA-approved and is intended for research use only.

The intranasal route is the primary and most-studied route for Selank because peptides in this class cross into the CNS more efficiently through the nasal mucosa. Subcutaneous injection is documented as an alternative route and is where the standard BAC-water reconstitution math applies. There is no strong head-to-head clinical comparison; the nasal route is favored in the published Russian literature.

For a 5 mg lyophilized vial, add 2 mL of bacteriostatic water slowly down the side of the vial and swirl gently until dissolved. That yields 2.5 mg/mL — a 250 mcg dose is 0.1 mL (10 units on a U-100 insulin syringe). Use the peptide calculator to compute exact draws for other vial sizes and target doses.

Selank has more clinical history than most research peptides — it was developed at the Institute of Molecular Genetics in Moscow and received Russian regulatory approval based on controlled trials for anxiety indications. However, large-scale Western clinical trials are lacking, and most published data comes from Russian and Eastern European research groups.

Unreconstituted lyophilized Selank should be refrigerated or frozen and protected from light. After reconstitution or once loaded into a nasal spray bottle, store at 2–8°C and use within about 30 days. Both nasal spray and reconstituted injectable forms are light- and heat-sensitive.

Next Steps

→ Peptide Calculator for exact syringe draw math (injectable route)
→ Full Peptide Dosage Chart to compare across compounds

Recommended Supplier

PSPeptides carries third-party tested, research-grade Selank with published COAs.

Discount Code: BANANAS10

Shop PSPeptides →

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Disclaimer: The information on this page is provided for research and educational purposes only. Selank is not approved by the FDA for human use. Nothing on this page constitutes medical advice. Consult a qualified healthcare professional before making any health-related decisions.