Sermorelin: Dosage, Calculator & Reconstitution Guide
GHRH analog studied for endogenous growth hormone stimulation — research context only.
What Is Sermorelin?
Sermorelin is the active 29-amino acid fragment of growth hormone-releasing hormone (GHRH) — the minimum sequence needed to bind the pituitary GHRH receptor. It was originally FDA-approved in 1997 under the brand name Geref for the diagnosis and treatment of pediatric growth hormone deficiency. Geref was later discontinued commercially, and sermorelin now exists primarily in the research and compounding market.
Mechanistically, sermorelin stimulates the anterior pituitary to release the body's own growth hormone in a pulsatile, feedback-regulated pattern. This is distinct from direct exogenous GH administration, which bypasses the pituitary and delivers a supraphysiologic bolus. Because endogenous GH release remains subject to somatostatin negative feedback, sermorelin's effect on GH/IGF-1 output is self-limiting.
Current adult-use evidence relies more on practitioner experience and older studies from the 1990s and 2000s than on modern large-scale randomized trials. Sermorelin is often positioned alongside newer GHRH analogs like tesamorelin and CJC-1295 (Modified GRF 1-29), which have longer half-lives.
This is a research-summary page. Nothing here constitutes a health claim or medical recommendation.
Common Research Doses
| Typical vial size | BAC water volume | Common dose range | Typical frequency |
|---|---|---|---|
| 5 mg | 2 mL | 100–500 mcg | Nightly (before sleep) |
| 10 mg | 2 mL | 100–500 mcg | Nightly (before sleep) |
Sermorelin is dosed in micrograms (mcg). Nightly administration is typical because endogenous GH secretion naturally peaks during early sleep, and GHRH-analog signaling amplifies that pulse.
Reconstitution Reference
Reconstitution is the process of dissolving lyophilized peptide powder in bacteriostatic water. Add BAC water slowly down the side of the vial, swirl gently until fully dissolved, and do not shake. Once reconstituted, store refrigerated.
| Vial size | BAC water | Concentration | Doses at 100 mcg | Doses at 250 mcg |
|---|---|---|---|---|
| 5 mg | 2.0 mL | 2.5 mg/mL (2500 mcg/mL) | 25 | 10 |
| 10 mg | 2.0 mL | 5.0 mg/mL (5000 mcg/mL) | 50 | 20 |
Compare all peptides on the Peptide Dosage Chart.
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Calculate Your Sermorelin Dose →Storage & Stability
| Item | State | Recommendation |
|---|---|---|
| Lyophilized vial | Sealed powder, unopened | Store at -20°C long-term; refrigerate for short-term |
| Reconstituted vial | In BAC water solution | Refrigerate at 2–8°C; use within 14–28 days |
| Bacteriostatic water | Multi-use vial | Room temperature; discard 28 days after first puncture |
| Light exposure | Any form | Protect from direct light; store in original box |
Sourcing
Recommended Supplier
PSPeptides carries third-party tested, research-grade sermorelin with published COAs.
Discount Code: BANANAS10
Website: pspeptides.com/?ref=bananas
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